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eQC In-Situ Energy Detector (patented)

The eQC is an energy meter permanently present in the sample chamber. It is there to allow a user to check the laser energy being delivered to the sample immediately before and after analytical runs and to confirm that the laser was working as expected. This can be particularly useful where long unattended runs are being undertaken as it gives the analyst the confidence that everything worked as required with consistent ablation parameters being delivered throughout. ​

Citations

[1] Van Malderen, S. J. M., Van Acker, T., & Vanhaecke, F. (2020). Sub-micrometer Nanosecond LA-ICP-MS Imaging at Pixel Acquisition Rates above 250 Hz via a Low-Dispersion Setup. Analytical Chemistry, 92(8), 5756-5764. https://doi.org/10.1021/acs.analchem.9b05056

[2] Van Acker, T., Van Malderen, S. J. M., Colina-Vegas, L., Ramachandran, R. K., & Vanhaecke, F. (2019). Selective ablation of biological tissue and single cells on a glass substrate by controlling the laser energy density of nanosecond 193 nm laser radiation. Journal of Analytical Atomic Spectrometry, 34(10), 1957-1964. https://doi.org/10.1039/c9ja00126c ​

Literature References

Title Authors
 Journal Year Application
Sub-µm nanosecond LA-ICP-MS imaging at pixel acquisition rates above 250 Hz via a low-dispersion setup Van Malderen et al. Analytical Chemistry
 2020 Fundamentals​
Methods to visualize elements in plants Kopittke et al. Plant Physiology 2020 Biological
Interactions of cisplatin and daunorubicin at the chromatic level Niaki et al. Scientific Reports 2020 Biological
Arraying of single cells for quantitative high throughput laser ablation ICP-TOF-MS Löhr et al. Analytical Chemistry 2019 Biological
Laser Ablation-Inductively Coupled Plasma Time-of-Flight Mass Spectrometry Imaging of Trace Elements at the Single-Cell Level for Clinical Practice Theiner et al. Analytical Chemistry 2019 Biological
Cellular and sub-cellular Cu isotope fractionation in the human neuroblastoma SH-SY5Y cell line: proliferating versus neuron-like cells Costas-Rodriguez et al. Analytical and Bioanalytical Chemistry 2019 Biological
Laser ablation-tandem ICP-mass spectrometry (LA-ICP-MS/MS) imaging of iron oxide nanoparticles in Ca-rich gelatin microspheres Van Acker et al. Journal of Analytical Atomic Spectrometry 2019 Biological
High-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass spectrometry for the determination of membranous receptor expression levels in breast cancer cell lines using receptor-specific hybrid tracers Van Acker et al. Analytica Chimica Acta 2019 Biological; Single Cell
Selective ablation of biological tissue and single cells on a glass substrate by controlling the laser energy density of nanosecond 193 nm laser radiation Van Acker et al. Journal of Analytical Atomic Spectrometry 2019 Biological
Three-dimensional reconstruction of the distribution of elemental tags in single cells using laser ablation ICP-mass spectrometry via registration approaches Van Malderen et al. Analytical and Bioanalytical Chemistry​
 2019 Biological ​

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